Principal investigators

Jens Ledet Jensen, Asger Hobolth

Research partners

• Jotun Hein, University of Oxford,
  Department of Statistics, UK
• Eric A. Stone, North Carolina State University,
  Bioinformatics Research Center, USA
• Jeffrey L. Thorne, North Carolina State University,
  Bioinformatics Research Center, USA

Focus Points

Analysis of high-dimensional data, inference in evolutionary models

Recent Publications

• A State Space Model Exhibiting a Cyclic Structure with an Application to Progesterone Concentration in Cow Milk
  Jørgen V. Hansen, Jens L. Jensen and Søren Højsgaard
• Hobolth, A. (2008). A Markov Chain Monte Carlo Expectation Maximization
  algorithm for statistical analysis of DNA sequence evolution with
  neighbour-dependent substitution rates. Journal of Computational and Graphical
  Statistics, to appear.
• Choi, S.C., Hobolth, A., Robinson, D.M., Kishino, H. and Thorne, J.L. (2007).
  Quantifying the Impact of Protein Tertiary Structure on Molecular Evolution.
  Molecular Biology and Evolution, 24, 1769-1782.
• Hobolth, A., Christensen, O.F., Mailund, T. and Schierup, M.H. (2007). Genomic
  relationships and speciation times of human, chimpanzee, and gorilla inferred
  from a coalescent hidden Markov model. PLoS Genetics, 3, 294-304.
• Hobolth, A., Nielsen, R., Wang, Y., Wu, F. and Tanksley, S.D. (2006).
  CpG+CpNpG analysis of protein coding sequences from tomato. Molecular Biology
  and Evolution, 23, 1318-1323.